Archive for March, 2022

Anthony Davis had to be carried off of the court after an apparent ankle injury 🥺 | NBA on ESPN

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Anthony Davis had to be carried off of the court after an apparent ankle injury 🥺 | NBA on ESPN

Anthony Davis left the game early after landing awkwardly on this right ankle in the Los Angeles Lakers’ home matchup against the Utah Jazz.

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Los Angeles Lakers vs New Orleans Pelicans – Full Game Highlights | March 27, 2022 NBA Season
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EP79: No cure for genital herpes but not all hopes lost | PUTTING DR G ON THE SPOT

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Consultant urologist Dr George Lee Eng Geap, or a.k.a Dr G, enlightens a reader on whether herpes simplex virus or genital herpes can be cured or not and what are the ways to keep the virus at bay.

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Hemolytic Disease of the Newborn, Animation

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(USMLE topics) Pathophysiology of HDN, Signs and Symptoms, Prevention and Treatment options.
This video is available for instant download licensing here: https://www.alilamedicalmedia.com/-/galleries/all-animations/heart-and-blood-circulation-videos/-/medias/3c52a09d-6812-4cf2-a9c4-98041f83f74d-hemolytic-disease-of-the-newborn-narrated-animation
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Voice by Ashley Fleming

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All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Hemolytic disease of the newborn, HDN, is a condition in which red blood cells of a newborn infant, or a perinatal fetus, are destroyed prematurely, resulting in anemia. HDN occurs when the blood types of the mother and baby are incompatible. A blood type refers to the presence or absence of a certain antigen, on the surface of a person’s red blood cells. Incompatibility happens when the baby has an antigen that the mother does not have. The mother’s immune system interprets the antigen as “foreign” and produces antibodies to target the cells carrying it for destruction.
While in principle HDN may occur with mismatch in any blood group, severe cases most commonly involve D-antigen of the Rh system. Specifically, HDN may develop if an Rh-negative mother, having no D-antigen, carries an Rh-positive fetus, with D-antigen. The first mismatch pregnancy, however, is usually not at risk. This is because the placenta normally does a good job separating the mother’s blood from the fetal blood, preventing the fetal red blood cells from being exposed to the mother’s immune system. However, at birth, or if a miscarriage or abortion occurs, the tearing of the placenta exposes fetal blood to the mother, who then responds by producing anti-D antibodies. Because antibody production takes some time, it does not affect the first baby; but if the mother is again pregnant with another Rh-positive fetus, her antibodies, being small enough to cross the placenta, can now cause hemolysis.
The first mismatch pregnancy may be at risk if the mother has previously been exposed to the antigen in other ways, such as through blood transfusion or sharing needles, or if the placental barrier is breached because of trauma, or medical procedures early in the pregnancy.
Anemia can cause heart failure, respiratory distress, and edema. Infants born with HDN also develop jaundice due to the accumulation of bilirubin, a yellow product of hemoglobin breakdown. Because red blood cells are destroyed rapidly and infants are unable to excrete bilirubin effectively, its levels rise quickly within 24h of birth. Bilirubin is toxic for brain tissues and may cause irreversible brain damage in a condition known as kernicterus. Other signs of HDN include enlarged liver, spleen, and presence of immature red blood cells, erythroblasts, in the blood. Some of these signs can be detected before birth, with ultrasound imaging.
HDN that involves D-antigen can now be effectively prevented with anti-D antibody. It is given to Rh-negative mothers during and soon after the first mismatch pregnancy. The antibody binds to fetal blood cells that leak into the mother’s blood, either destroying them, or hiding them from the mother’s immune system, thus preempting the mother’s immune response.
Infants born with HDN are usually treated with intravenous fluid, and phototherapy, a procedure in which a certain spectrum of light is used to convert bilirubin to a form that is easier for the infant to excrete.
Severe anemia may be treated with:
– blood transfusion,
– intravenous immunoglobulin G therapy, which works by blocking the destruction of antibody-coated red blood cells.
– and exchange transfusion, where the baby’s blood is essentially replaced with Rh-negative donor blood. This procedure is very effective at removing bilirubin and reducing the destructive effect of the mother’s antibody, but may have adverse effects.
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(USMLE topics, cardiology) Life and death of erythrocytes, anemia and polycythemia. This video is available for instant download licensing here: https://www.alilamedicalmedia.com/-/galleries/all-animations/heart-and-blood-circulation-videos/-/medias/5519909f-97f9-44f6-a806-0c87af9addb7-red-blood-cell-disorders-narrated-animation
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All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Production of red blood cells occurs in the red bone marrow, and is stimulated by erythropoietin, EPO. EPO is secreted predominantly by the kidneys. The kidneys sense oxygen levels in the blood and adjust EPO secretion accordingly to the body’s needs.
Red cells live about 100 to 120 days. With age, the cells lose their elasticity. Without protein synthesis, they are unable to repair themselves. Worn-out red cells are detected in the spleen, which serves as a quality control center. The spleen has a network of very narrow channels which test the agility of erythrocytes. Healthy cells can bend and fold to squeeze through, while old cells, being rigid and fragile, get stuck and are destroyed by macrophages. Parts of the dead cells are salvaged to make new cells. Part of the heme is secreted into bile and disposed in feces.
The number of red blood cells is strictly regulated and has important clinical significance. Common measurements include red blood cell count, hematocrit, and hemoglobin concentration.
An imbalance between the rate of red cell production and death can result in their deficiency, known as anemia, or excess, known as polycythemia.
Anemia can be caused by blood loss, insufficient erythrocyte production, or their premature destruction.
Insufficient red cell production can result from:
+ deficiency of any of the nutrients that are required for their formation,
+ impaired kidney function, which leads to lower secretion of EPO,
+ or destruction of the bone marrow tissue responsible for red cell production. This can happen because of inherited mutations, autoimmune diseases, or exposure to chemicals, drugs or radiation; but causes are unknown for many cases. Reduced erythropoiesis is known as hypoplastic anemia, while complete cessation of red cell production is called aplastic anemia.
Inappropriate destruction of red blood cells, also called hemolytic anemia, can be inherited or acquired. The inherited forms are usually due to defects within red cells themselves, such as abnormalities in hemoglobin structure, while acquired hemolytic anemia can be caused by toxins, drugs, autoimmune diseases, infection, overactive spleen, or blood group mismatch.
Anemia results in low oxygen levels in the blood, known as hypoxemia. Mild anemia causes weakness and confusion, while severe anemia may lead to organ failure due to lack of oxygen and is life-threatening.
Excess red cell production, or polycythemia, can be primary or secondary. Primary polycythemia, or polycythemia vera, is a form of blood cancer, where the bone marrow produces too many blood cells. Secondary polycythemia, on the other hand, is a consequence of low oxygen state, which induces the kidneys to produce more erythropoietin, subsequently leading to more erythrocytes. Causes include smoking, air pollution, emphysema, living at high altitudes, and physical strenuous conditioning in athletes.
Excess red cells may increase blood volume, blood pressure, and viscosity. This augments the risks for blood clot formation, which may lead to heart attacks, strokes, and pulmonary embolism. The heart also has to work harder to manage larger amount of thicker blood and heart failures may result.

JJ Chalmers Reflects on IED Injury | Exclusive Q&A

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In this exclusive, must-see Q&A clip, JJ Chalmers reflects on how his life has been, following the injury he sustained in the Marines, as well as how he coped mentally with the huge life adjustment.

A champion for disability representation, JJ’s open discussion sends a clear message of self-acceptance to others who have been severely injured or born with disabilities. This interview was opened our eyes to the process of recovery, and JJ’s immense strength.

Who is JJ Chalmers?

Former Royal Marine Commando turned motivational speaker and television presenter, JJ Chalmers epitomises the mental resilience and determination required to overcome adversity. Most recently, JJ was listed in Strictly Come Dancing’s 2020 celebrity lineup, finishing in the quarter-finals of the competition.

Sustaining a severe injury whilst in combat was not the end of JJ’s story; he fought to not only live but thrive, going on to win gold at the Invictus Games and carve out a new career in television presenting and public speaking.

With first-hand experience of the qualities required to be undeterred by defeat, JJ makes the ideal speaker for a range of demographics, facing business dilemmas, personal challenges or looking for inspiration, a truly compelling speaker. A truly captivating and inspirational speaker, JJ Chalmers can offer transformative talks to your audience when you hire him for an event.

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Contact the Champions Speakers agency to provisionally enquire about JJ Chalmers for your event today. Simply call a booking agent on 0207 1010 553 or email us at agent@championsukplc.com for more information.

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JJ Chalmers speaking to Champions Speakers in 2021.

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H. Pylori's Nauseous Side Effects

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H. Pylori’s Nauseous Side Effects – Dr. J Live Q & A

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H. pylori is a gut infection that can create digestive, energy, and mood issues. A common side effect is a nausea , today Dr. J will explore this and answer your Q&A at the end.

The endotoxins of h. pylori create gut permeability, inflammation, and stress in the gut. It can also make you pretty gassy and raise your PH levels (i.e making you less acidic and more alkaline). Without the right amount of acidity your body will struggle or be unable to digest, assimilate, and absorb the nutrients you need to function (hence the energy and mood issues). Alongside this, you’ve got that nauseous I-need-to-puke feeling that just won’t go away.

So what can you do? Dr. J suggests you see a functional medicine doctor and get a comprehensive plan to treat the h. pylori. Meanwhile to help relieve that queasy feeling, try some ginger tea (which has excellent anti-nausea, anti-inflammatory, and anti-biofilm properties). Add some enzymes to your list to help encourage digestion, if these don’t ‘move the needle’ try adding some acid (a shot of apple cider vinegar in water before each meal). Dr. J offers other easily implemented tips and gets to your Qs about: the right amount of Zinc you should take; if berberines help lower PH levels; what to prioritize in a senior who might have h.pylori; if h.pylori is reaccuring; how probiotics can help with your h.pylori treatment plan, and more!

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Have you recently been diagnosed with high blood pressure? Has your doctor recommended taking Hydrochlorothiazide as part of your treatment? Learn about the most common side effects as well as the more rare ones that you should watch out for. Starting a new medication can be scary so be informed.

Medication is not the only way that you should treat your high blood pressure. Many times through lifestyle changes like diet and exercise as well as managing your stress you can make a big impact on controlling it. For some simple steps you can start with in your diet watch my video on how to approach weight loss:

Monitoring your blood pressure at home is a critical element to keeping your blood pressure under control. When it’s high you typically don’t have symptoms and oftentimes when you come see me you get nervous and your blood pressure goes up. It’s very helpful if you are taking it on a regular basis at home so we can tell if we need to make some adjustments. Here are a few options in blood pressure monitors that can help you with this:

OMRON 10 Series Wireless Upper Arm Blood Pressure Monitor
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iProvèn Wrist Blood Pressure Monitor Watch
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Omron Evolv Bluetooth Wireless Upper Arm Blood Pressure Monitor
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Blood Pressure Down: The 10-Step Plan to Lower Your Blood Pressure in 4 Weeks–Without Prescription Drugs
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Thirty Days to Natural Blood Pressure Control: The “No Pressure” Solution
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The Mediterranean DASH Diet Cookbook: Lower Your Blood Pressure and Improve Your Health
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2117 Chapter 14 – Principles of Disease and Epidemiology

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